Proton Pump Inhibitors
From Holoprosencephaly
Proton Pump Inhibitors
Brand Names
Esomeprazole (Nexium) Lansoprazole (Prevacid) Omeprazole (Prilosec)
Uses:
Proton pump inhibitors are medications that reduce the production of stomach acid by stopping the mechanism inside cells that pumps acid to the stomach. These drugs are generally considered to be the most effective treatment for suppressing the production of stomach acid.
These are available by prescription and are used to treat conditions such as peptic ulcers, gastroesophageal reflux disease (GERD), indigestion, Zollinger-Ellison syndrome (ZES) and used in combination with other medications to eliminate H. pylori, a bacteria that causes ulcers. Omeprazole (Prilosec) is available in an over-the-counter form.
All Proton Pump Inhibitors work similarly to one another. They do, however, differ in their drug interactions and how they are processed by the liver. In addition, some PPIs demonstrate longer lasting effects and therefore may be taken less frequently.
Forms:
Omeprazole (Prilosec) comes as a delayed-release capsule, a nonprescription delayed-release tablet, a powder for suspension, and a regular capsule. Lansoprazole (Prevacid) comes as a delayed-release (long-acting) capsule and granules to make a delayed-release solution (liquid) to take by mouth. Esomeprazole (Nexium) comes as a delayed-release (long-acting) capsule to take by mouth in a tablet or capsule form.
Side effects:
Note--this is an incomplete list of potential side effects. Ask your physician or pharmacist for a complete list of side effects caused by the prescribed medication.
Tell your doctor if any of these symptoms are severe or do not go away:
•stomach pain •diarrhea •constipation •dizziness •cough •back pain •gas •headache
Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately:
•rash •hives •itching •swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs •difficulty breathing or swallowing •hoarseness •seizures •muscle spasms, tightening, aching, or cramping •burning or tingling of the lips, tongue, hands, or feet
Proton Pump Inhibitors may cause other side effects. Symptoms of overdose can be similar to the medication’s side effects but are usually more severe. Call your doctor if you have any unusual problems while taking your medication.
Precautions:
- Notify your physician and pharmacist of any allergies.
- Patients who have certain medical conditions – such as liver or kidney damage and/or problems with sodium or potassium regulation should notify physician.
- If you are taking digoxin (Lanoxin, Lanoxicaps), iron supplements, vitamins that contain iron, or ketoconazole (Nizoral), you should notify your physician because these medications cannot be taken within 2 hours of taking Proton Pump Inhibitors.
- Sucralfate (Carafate)must be taken at least 30 minutes after Lansoprazole (Prevacid)
- Tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking. Be sure to mention any of the following: ampicillin (Omnipen, Polycillin, Totacillin), digoxin (Lanoxin), ketoconazole (Nizoral), theophylline (Theo-bid, TheoDur), diazepam (anxiety medicine) and vitamins containing iron. Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
For more detailed information about Proton Pump Inhibitors, ask your healthcare provider.
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